Molecular epidemiological and clinical aspects of enterovirus infection in the south of Russia

Objective : the study of molecular epidemiological and clinical aspects EVI in Rostov region for period 2006-2020. to improve disease surveillance system. Research methods: epidemiological, virological, biological (PCR, sequencing, phylogenetic analysis), microbiological, statistical. Materials methods analysis medical records 139 patients with was carried out. Samples biomaterial (feces, throat swab) from 17293 people, samples environmental objects (2710 samples), strains enteroviruses (EV) amount 142 specimens were studied. Results until 2013. sporadic incidence prevailed registration 1 38 cases per year. June 2013 there a sharp increase formation local foci organized groups, associated circulation new genotype — EV 71 type subgenotype C4 “Chinese” origin (622 registered, one death). The features determined: acute onset manifestations intoxication, foot mouth disease-like syndromes, followed by development CNS pathology 37.4% patients. According results sequencing virus carriers EVs 22 types detected. Conclusions are subject intense genetic variability, due which genovariants pathogenic humans may appear. change genotypes, dominated among population region, determined rise A significant diversity non-polio genotypes revealed, while structure changed different years.